RAS guanyl-releasing protein 1 · SINGLE PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt O95267. Use UniProt O95267 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O95267 as the stable identity anchor, then attach disease evidence before program review.
RAS guanyl-releasing protein 1
Review this target as RAS guanyl-releasing protein 1, mapped to UniProt O95267. Sequence length is 797 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats RAS guanyl-releasing protein 1 as ChEMBL target CHEMBL5953, mapped to UniProt O95267. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | RAS guanyl-releasing protein 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O95267 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | RAS guanyl-releasing protein 1 |
| UniProt Accession | O95267 |
| Component Type | Protein |
| Sequence Length | 797 aa |
RAS guanyl-releasing protein 1
Review this target as RAS guanyl-releasing protein 1, mapped to UniProt O95267. Sequence length is 797 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL519741 | 9.6 | Ki | 0.25 | Preclinical |
| CHEMBL3289012 | 9.39 | Ki | 0.41 | Preclinical |
| CHEMBL3289014 | 9.16 | Ki | 0.69 | Preclinical |
| CHEMBL3289013 | 9.06 | Ki | 0.87 | Preclinical |
| CHEMBL3289011 | 8.81 | Ki | 1.55 | Preclinical |
| CHEMBL4070999 | 7.65 | Ki | 22.6 | Preclinical |
| CHEMBL4097154 | 7.65 | Ki | 22.6 | Preclinical |
| CHEMBL4075373 | 7.5 | Ki | 31.3 | Preclinical |
| CHEMBL4069954 | 7.4 | Ki | 40.0 | Preclinical |
| CHEMBL4099579 | 7.2 | Ki | 63.3 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 5 | 1 | 5.7 |
| assay format | 2 | 8 | 7.5 |
| single protein format | 1 | 5 | 9.2 |