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Target Snapshot

CHEMBL5955 Target Snapshot

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit · SINGLE PROTEIN · Homo sapiens

123Compounds
36Assays
0Approved Drugs
80.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt O15294. Use UniProt O15294 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt O15294 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Protein anchor
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

Review this target as UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, mapped to UniProt O15294. Sequence length is 1046 aa.

Protein source · UniProt accession via ChEMBL component mapping
UniProt O15294 Protein 1046 aa
Open protein block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit as ChEMBL target CHEMBL5955, mapped to UniProt O15294. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL5955
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
O15294
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

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Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
UniProt AccessionO15294
Component TypeProtein
Sequence Length1046 aa

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, mapped to UniProt O15294. Sequence length is 1046 aa.

Mapped IDO15294
Review nameUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Phase II
Assay Mix

Activity Type Distribution

IC5041.0
KI10.0
KD29.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1232461 6.65 Kd 223.0 Clinical
CHEMBL3695712 6.4 Kd 400.0 Preclinical
CHEMBL1232461 6.32 IC50 480.0 Clinical
CHEMBL3695701 5.8 Kd 1600.0 Preclinical
CHEMBL130266 5.75 IC50 1800.0 Preclinical
CHEMBL3691687 5.7 Kd 2000.0 Preclinical
CHEMBL5559419 5.57 IC50 2700.0 Preclinical
CHEMBL3691691 5.5 Kd 3200.0 Preclinical
CHEMBL3695711 5.4 Kd 4000.0 Preclinical
CHEMBL3695706 5.39 Kd 4100.0 Preclinical
Distribution

pChEMBL Value Distribution

17
5.0
5
5.5
2
6.0
1
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

36
Total Assays
54
Tested Compounds
1
Assay Types
Binding — 36 assays, 54 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 31 54 4.9
cell-based format 5 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine