Beta-lactamase SHV-1 · SINGLE PROTEIN · Escherichia coli
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As of 2026-09-13Protein identity stays anchored to UniProt P0AD63. Use UniProt P0AD63 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P0AD63 as the stable identity anchor, then attach disease evidence before program review.
Beta-lactamase SHV-1
Review this target as Beta-lactamase SHV-1, mapped to UniProt P0AD63. Sequence length is 286 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Beta-lactamase SHV-1 as ChEMBL target CHEMBL5956, mapped to UniProt P0AD63. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Beta-lactamase SHV-1 is the right protein anchor across sources, using UniProt P0AD63 as the stable mapping.
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| Preferred Name | Beta-lactamase SHV-1 |
| Target Type | SINGLE PROTEIN |
| Organism | Escherichia coli |
| UniProt | P0AD63 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Beta-lactamase SHV-1 |
| UniProt Accession | P0AD63 |
| Component Type | Protein |
| Sequence Length | 286 aa |
Beta-lactamase SHV-1
Review this target as Beta-lactamase SHV-1, mapped to UniProt P0AD63. Sequence length is 286 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4114803 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL4111477 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL4114749 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL4106598 | 8.59 | IC50 | 2.6 | Preclinical |
| CHEMBL4114669 | 8.49 | IC50 | 3.2 | Preclinical |
| CHEMBL4106976 | 8.38 | IC50 | 4.2 | Preclinical |
| CHEMBL4109897 | 8.37 | IC50 | 4.3 | Preclinical |
| CHEMBL122450 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL4115687 | 7.86 | IC50 | 13.9 | Preclinical |
| CHEMBL4114672 | 7.65 | IC50 | 22.6 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 10 | 12 | 6.8 |
| assay format | 1 | 33 | 6.8 |
| cell-based format | 1 | 3 | 5.4 |