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Target Snapshot

CHEMBL5963 Target Snapshot

Proteinase-activated receptor 2 · SINGLE PROTEIN · Homo sapiens

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411Compounds
146Assays
0Approved Drugs
573.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P55085. Use UniProt P55085 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P55085 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Proteinase-activated receptor 2 as ChEMBL target CHEMBL5963, mapped to UniProt P55085. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Proteinase-activated receptor 2
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL5963
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P55085
Proteinase-activated receptor 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Proteinase-activated receptor 2 is the right protein anchor across sources, using UniProt P55085 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameProteinase-activated receptor 2
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP55085
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProteinase-activated receptor 2
UniProt AccessionP55085
Component TypeProtein
Sequence Length397 aa

Proteinase-activated receptor 2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Proteinase-activated receptor 2, mapped to UniProt P55085. Sequence length is 397 aa.

Mapped IDP55085
Review nameProteinase-activated receptor 2
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Phase III
Assay Mix

Activity Type Distribution

IC50346.0
KI4.0
EC50223.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5273903 9.15 IC50 0.7 Preclinical
CHEMBL3582248 8.7 IC50 2.0 Preclinical
CHEMBL3582250 8.7 IC50 2.0 Preclinical
CHEMBL4470628 8.7 IC50 2.0 Preclinical
CHEMBL2431724 8.4 EC50 4.0 Preclinical
CHEMBL3582251 8.38 IC50 4.2 Preclinical
CHEMBL463763 7.85 IC50 14.0 Clinical
CHEMBL4100763 7.75 EC50 18.0 Preclinical
CHEMBL4128763 7.64 IC50 23.0 Preclinical
CHEMBL5431335 7.64 IC50 23.0 Preclinical
Distribution

pChEMBL Value Distribution

141
5.0
101
5.5
73
6.0
43
6.5
26
7.0
15
7.5
6
8.0
3
8.5
1
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

146
Total Assays
146
Tested Compounds
4
Assay Types
Functional — 92 assays, 146 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 92 146 6.1
Binding — 50 assays, 139 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 23 78 5.7
assay format 16 56 5.1
single protein format 11 5 6.6
ADME — 3 assays, 6 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 6 5.4
Unassigned — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine