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Target Snapshot

CHEMBL5968 Target Snapshot

Lysophosphatidic acid receptor 4 · SINGLE PROTEIN · Homo sapiens

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47Compounds
20Assays
0Approved Drugs
40.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q99677. Use UniProt Q99677 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q99677 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Lysophosphatidic acid receptor 4 as ChEMBL target CHEMBL5968, mapped to UniProt Q99677. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Lysophosphatidic acid receptor 4
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL5968
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q99677
Lysophosphatidic acid receptor 4
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Lysophosphatidic acid receptor 4 is the right protein anchor across sources, using UniProt Q99677 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameLysophosphatidic acid receptor 4
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ99677
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelLysophosphatidic acid receptor 4
UniProt AccessionQ99677
Component TypeProtein
Sequence Length370 aa

Lysophosphatidic acid receptor 4

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Lysophosphatidic acid receptor 4, mapped to UniProt Q99677. Sequence length is 370 aa.

Mapped IDQ99677
Review nameLysophosphatidic acid receptor 4
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC5012.0
KI2.0
EC5026.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2335051 8.62 EC50 2.4 Preclinical
CHEMBL357053 8.57 EC50 2.692 Preclinical
CHEMBL2017139 8.48 EC50 3.3 Preclinical
CHEMBL2335047 8.46 EC50 3.467 Preclinical
CHEMBL2335049 8.42 EC50 3.8 Preclinical
CHEMBL2335052 8.42 EC50 3.8 Preclinical
CHEMBL2335050 8.35 EC50 4.467 Preclinical
CHEMBL153043 8.31 EC50 4.898 Preclinical
CHEMBL2335048 8.31 EC50 4.898 Preclinical
CHEMBL117021 8.09 EC50 8.1 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
1
5.5
1
6.0
3
6.5
2
7.0
0
7.5
16
8.0
4
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

20
Total Assays
12
Tested Compounds
2
Assay Types
Functional — 15 assays, 6 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 11 6 6.0
assay format 2 0 —
single protein format 2 0 —
Binding — 5 assays, 12 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 12 8.2
single protein format 2 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine