Protein smoothened · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein smoothened shows approved-linked disease relevance led by basal cell carcinoma. 5 more disease programs remain visible in the same review block. 6 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q99835. Start with basal cell carcinoma, then reuse UniProt Q99835 as the stable protein anchor across project notes and exports.
Start with basal cell carcinoma, then reuse UniProt Q99835 as the stable protein anchor across project notes and exports.
Protein smoothened shows approved-linked disease relevance led by basal cell carcinoma. 5 more disease programs remain visible in the same review block. 6 linked drugs remain visible in the same block.
Start review with basal cell carcinoma because it currently carries approved-linked support. Linked drugs include BMS-833923, LEQ506, PATIDEGIB, SONIDEGIB PHOSPHATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyProtein smoothened
Review this target as Protein smoothened, mapped to UniProt Q99835. Sequence length is 787 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Protein smoothened as ChEMBL target CHEMBL5971, mapped to UniProt Q99835. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Protein smoothened is the right protein anchor across sources, using UniProt Q99835 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why basal cell carcinoma is currently framed as approved-linked support. It currently carries 6 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Protein smoothened |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q99835 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Protein smoothened |
| UniProt Accession | Q99835 |
| Component Type | Protein |
| Sequence Length | 787 aa |
Protein smoothened
Review this target as Protein smoothened, mapped to UniProt Q99835. Sequence length is 787 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Protein smoothened shows approved-linked disease relevance led by basal cell carcinoma. 5 more disease programs remain visible in the same review block.
Start review with basal cell carcinoma because it currently carries approved-linked support. Linked drugs include BMS-833923, LEQ506, PATIDEGIB, SONIDEGIB PHOSPHATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4632769 | 10.1 | IC50 | 0.08 | Preclinical |
| CHEMBL4637222 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL1083915 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL473417 | 9.4 | IC50 | 0.4 | Approved |
| CHEMBL4632769 | 9.3 | EC50 | 0.5 | Preclinical |
| CHEMBL1086467 | 9.15 | IC50 | 0.7 | Preclinical |
| CHEMBL1209455 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL538867 | 8.85 | IC50 | 1.4 | Clinical |
| CHEMBL4637222 | 8.82 | EC50 | 1.5 | Preclinical |
| CHEMBL473417 | 8.7 | EC50 | 2.0 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 75 | 392 | 6.8 |
| single protein format | 24 | 67 | 6.8 |
| assay format | 7 | 159 | 7.2 |
| tissue-based format | 3 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 14 | 143 | 7.0 |
| assay format | 4 | 6 | 6.9 |