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Target Snapshot

CHEMBL5973 Target Snapshot

Carbonic anhydrase 15 · SINGLE PROTEIN · Mus musculus

149Compounds
16Assays
22Approved Drugs
134.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q99N23. Use UniProt Q99N23 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q99N23 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Carbonic anhydrase 15 as ChEMBL target CHEMBL5973, mapped to UniProt Q99N23. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Carbonic anhydrase 15
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL5973
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q99N23
Carbonic anhydrase 15
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Carbonic anhydrase 15 is the right protein anchor across sources, using UniProt Q99N23 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCarbonic anhydrase 15
UniProt AccessionQ99N23
Component TypeProtein
Sequence Length324 aa

Carbonic anhydrase 15

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Carbonic anhydrase 15, mapped to UniProt Q99N23. Sequence length is 324 aa.

Mapped IDQ99N23
Review nameCarbonic anhydrase 15
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

22
Approved
8
Phase III
2
Phase II
1
Phase 0.5
Assay Mix

Activity Type Distribution

IC501.0
KI133.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL71611 7.52 Ki 30.0 Preclinical
CHEMBL352535 7.47 Ki 34.0 Preclinical
CHEMBL118 7.35 Ki 45.0 Approved
CHEMBL568173 7.34 Ki 46.0 Preclinical
CHEMBL265674 7.32 Ki 48.0 Preclinical
CHEMBL456724 7.32 Ki 48.0 Preclinical
CHEMBL266026 7.31 Ki 49.0 Preclinical
CHEMBL6753 7.31 Ki 49.0 Preclinical
CHEMBL18 7.24 Ki 58.0 Approved
CHEMBL360356 7.22 Ki 60.0 Preclinical
Distribution

pChEMBL Value Distribution

35
5.0
4
5.5
16
6.0
0
6.5
43
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

LACOSAMIDE
CHEMBL58323
Approved 2008
NILOTINIB
CHEMBL255863
Approved 2007
VALDECOXIB
CHEMBL865
Approved 2001
IMATINIB
CHEMBL941
Approved 2001
ZONISAMIDE
CHEMBL750
Approved 2000
CELECOXIB
CHEMBL118
Approved 1998
BRINZOLAMIDE
CHEMBL220491
Approved 1998
TOPIRAMATE
CHEMBL220492
Approved 1996
DORZOLAMIDE
CHEMBL218490
Approved 1994
ETHOXZOLAMIDE
CHEMBL18
Approved 1982
DOBUTAMINE
CHEMBL926
Approved 1978
MAFENIDE
CHEMBL419
Approved 1969
METHAZOLAMIDE
CHEMBL19
Approved 1959
DICHLORPHENAMIDE
CHEMBL17
Approved 1958
ACETAZOLAMIDE
CHEMBL20
Approved 1953
Assay Landscape

Assay Landscape

16
Total Assays
107
Tested Compounds
1
Assay Types
Binding — 16 assays, 107 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 13 103 6.0
assay format 2 0
cell-based format 1 4 4.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine