Cytochrome P450 2E1 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P05182. Use UniProt P05182 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P05182 as the stable identity anchor, then attach disease evidence before program review.
Cytochrome P450 2E1
Review this target as Cytochrome P450 2E1, mapped to UniProt P05182. Sequence length is 493 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cytochrome P450 2E1 as ChEMBL target CHEMBL5978, mapped to UniProt P05182. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Cytochrome P450 2E1 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P05182 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cytochrome P450 2E1 |
| UniProt Accession | P05182 |
| Component Type | Protein |
| Sequence Length | 493 aa |
Cytochrome P450 2E1
Review this target as Cytochrome P450 2E1, mapped to UniProt P05182. Sequence length is 493 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL464300 | 5.44 | IC50 | 3600.0 | Preclinical |
| CHEMBL536056 | 5.44 | IC50 | 3600.0 | Preclinical |
| CHEMBL541899 | 5.3 | IC50 | 5000.0 | Preclinical |
| CHEMBL535613 | 5.22 | IC50 | 6000.0 | Preclinical |
| CHEMBL537200 | 4.85 | IC50 | 14000.0 | Preclinical |
| CHEMBL535614 | 4.7 | IC50 | 20000.0 | Preclinical |
| CHEMBL552550 | 4.52 | IC50 | 30000.0 | Preclinical |
| CHEMBL1908229 | 4.0 | Ki | 100000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 4 | 3 | 4.0 |
| tissue-based format | 4 | 6 | 5.0 |
| microsome format | 3 | 2 | 5.4 |
| assay format | 2 | 0 | — |