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Target Snapshot

CHEMBL5989 Target Snapshot

Baculoviral IAP repeat-containing protein 5 · SINGLE PROTEIN · Homo sapiens

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64Compounds
65Assays
1Approved Drugs
45.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Baculoviral IAP repeat-containing protein 5 shows clinical signal disease relevance led by glioblastoma multiforme. 3 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt O15392. Start with glioblastoma multiforme, then reuse UniProt O15392 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with glioblastoma multiforme, then reuse UniProt O15392 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 1 linked drug
Open source guide
Disease program
glioblastoma multiforme

Baculoviral IAP repeat-containing protein 5 shows clinical signal disease relevance led by glioblastoma multiforme. 3 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with glioblastoma multiforme because it currently carries clinical signal support. Linked drugs include SVN53-67/M57-KLH PEPTIDE VACCINE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Clinical signal Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Baculoviral IAP repeat-containing protein 5 as ChEMBL target CHEMBL5989, mapped to UniProt O15392. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Baculoviral IAP repeat-containing protein 5
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL5989
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
O15392
Baculoviral IAP repeat-containing protein 5
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Baculoviral IAP repeat-containing protein 5 is the right protein anchor across sources, using UniProt O15392 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why glioblastoma multiforme is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.

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Evidence Card
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Overview

Basic Information

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Preferred NameBaculoviral IAP repeat-containing protein 5
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtO15392
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBaculoviral IAP repeat-containing protein 5
UniProt AccessionO15392
Component TypeProtein
Sequence Length142 aa

Baculoviral IAP repeat-containing protein 5

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Baculoviral IAP repeat-containing protein 5, mapped to UniProt O15392. Sequence length is 142 aa.

Mapped IDO15392
Review nameBaculoviral IAP repeat-containing protein 5
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Clinical signal Open Targets-ready proxy

Baculoviral IAP repeat-containing protein 5 shows clinical signal disease relevance led by glioblastoma multiforme. 3 more disease programs remain visible in the same review block.

Clinical signal Phase II
glioblastoma multiforme
1 linked drug · 1 direct · 1 efficacy
Linked drugSVN53-67/M57-KLH PEPTIDE VACCINE
Clinical signal Phase II
gliosarcoma
1 linked drug · 1 direct · 1 efficacy
Linked drugSVN53-67/M57-KLH PEPTIDE VACCINE
Clinical signal Phase I
multiple myeloma
1 linked drug · 1 direct · 1 efficacy
Linked drugSVN53-67/M57-KLH PEPTIDE VACCINE
Clinical signal Phase I
plasma cell leukemia
1 linked drug · 1 direct · 1 efficacy
Linked drugSVN53-67/M57-KLH PEPTIDE VACCINE
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with glioblastoma multiforme because it currently carries clinical signal support. Linked drugs include SVN53-67/M57-KLH PEPTIDE VACCINE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseglioblastoma multiforme
Strongest levelClinical signal
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC507.0
KD38.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2105734 8.55 IC50 2.8 Clinical
CHEMBL4793552 7.47 Kd 34.0 Preclinical
CHEMBL234358 7.43 Kd 37.0 Preclinical
CHEMBL233848 7.32 Kd 48.0 Preclinical
CHEMBL272921 7.22 Kd 60.0 Preclinical
CHEMBL234330 7.19 Kd 64.0 Preclinical
CHEMBL234040 7.12 Kd 76.0 Preclinical
CHEMBL232404 7.07 Kd 86.0 Preclinical
CHEMBL234421 7.0 Kd 100.0 Preclinical
CHEMBL234041 6.7 Kd 200.0 Preclinical
Distribution

pChEMBL Value Distribution

7
5.0
2
5.5
11
6.0
4
6.5
9
7.0
1
7.5
3
8.0
2
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

65
Total Assays
37
Tested Compounds
2
Assay Types
Binding — 63 assays, 37 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 47 30 6.6
single protein format 13 4 5.6
assay format 2 3 6.7
subcellular format 1 0 —
Functional — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 2 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine