Serine/threonine-protein kinase RIO2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q9BVS4. Use UniProt Q9BVS4 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9BVS4 as the stable identity anchor, then attach disease evidence before program review.
Serine/threonine-protein kinase RIO2
Review this target as Serine/threonine-protein kinase RIO2, mapped to UniProt Q9BVS4. Sequence length is 552 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Serine/threonine-protein kinase RIO2 as ChEMBL target CHEMBL6000, mapped to UniProt Q9BVS4. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Serine/threonine-protein kinase RIO2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9BVS4 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Serine/threonine-protein kinase RIO2 |
| UniProt Accession | Q9BVS4 |
| Component Type | Protein |
| Sequence Length | 552 aa |
Serine/threonine-protein kinase RIO2
Review this target as Serine/threonine-protein kinase RIO2, mapped to UniProt Q9BVS4. Sequence length is 552 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5172767 | 8.21 | Kd | 6.1 | Preclinical |
| CHEMBL5174723 | 8.14 | Kd | 7.3 | Preclinical |
| CHEMBL5199096 | 8.08 | Kd | 8.4 | Preclinical |
| CHEMBL5190698 | 7.75 | Kd | 18.0 | Preclinical |
| CHEMBL5399070 | 7.72 | Kd | 19.0 | Preclinical |
| CHEMBL5184015 | 7.32 | Kd | 47.5 | Preclinical |
| CHEMBL5417058 | 7.32 | Kd | 48.0 | Preclinical |
| CHEMBL5192566 | 7.31 | Kd | 49.0 | Preclinical |
| CHEMBL535 | 7.31 | Kd | 49.0 | Approved |
| CHEMBL5417476 | 7.28 | Kd | 53.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 72 | 39 | 6.3 |
| assay format | 32 | 20 | 6.8 |
| cell-based format | 14 | 13 | 5.2 |
| subcellular format | 8 | 0 | — |
| tissue-based format | 1 | 0 | — |