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Target Snapshot

CHEMBL6007 Target Snapshot

Transient receptor potential cation channel subfamily A member 1 · SINGLE PROTEIN · Homo sapiens

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2,254Compounds
322Assays
5Approved Drugs
2,778.0Activities
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Broader Open DB context

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Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Transient receptor potential cation channel subfamily A member 1 shows approved-linked disease relevance led by Arthralgia. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt O75762. Start with Arthralgia, then reuse UniProt O75762 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with Arthralgia, then reuse UniProt O75762 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 1 linked drug
Open source guide
Disease program
Arthralgia

Transient receptor potential cation channel subfamily A member 1 shows approved-linked disease relevance led by Arthralgia. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with Arthralgia because it currently carries approved-linked support. Linked drugs include MENTHOL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Transient receptor potential cation channel subfamily A member 1 as ChEMBL target CHEMBL6007, mapped to UniProt O75762. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Transient receptor potential cation channel subfamily A member 1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL6007
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
O75762
Transient receptor potential cation channel subfamily A member 1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Transient receptor potential cation channel subfamily A member 1 is the right protein anchor across sources, using UniProt O75762 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why Arthralgia is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

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Evidence Card
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Overview

Basic Information

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Preferred NameTransient receptor potential cation channel subfamily A member 1
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtO75762
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelTransient receptor potential cation channel subfamily A member 1
UniProt AccessionO75762
Component TypeProtein
Sequence Length1119 aa

Transient receptor potential cation channel subfamily A member 1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Transient receptor potential cation channel subfamily A member 1, mapped to UniProt O75762. Sequence length is 1119 aa.

Mapped IDO75762
Review nameTransient receptor potential cation channel subfamily A member 1
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Transient receptor potential cation channel subfamily A member 1 shows approved-linked disease relevance led by Arthralgia. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
Arthralgia
1 linked drug · 1 direct · 1 efficacy
Linked drugMENTHOL
Approved-linked Approved
arthritis
1 linked drug · 1 direct · 1 efficacy
Linked drugMENTHOL
Approved-linked Approved
asthma
1 linked drug · 1 direct · 1 efficacy
Linked drugMENTHOL
Approved-linked Approved
Back pain
1 linked drug · 1 direct · 1 efficacy
Linked drugMENTHOL
Approved-linked Approved
bronchitis
1 linked drug · 1 direct · 1 efficacy
Linked drugMENTHOL
Approved-linked Approved
burn
1 linked drug · 1 direct · 1 efficacy
Linked drugMENTHOL
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with Arthralgia because it currently carries approved-linked support. Linked drugs include MENTHOL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseArthralgia
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

5
Approved
5
Phase III
14
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC502,395.0
EC50383.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1084637 10.3 EC50 0.05 Preclinical
CHEMBL1084640 10.12 EC50 0.07586 Preclinical
CHEMBL1085102 10.0 EC50 0.1 Preclinical
CHEMBL1256241 10.0 EC50 0.1 Preclinical
CHEMBL1084097 9.96 EC50 0.11 Preclinical
CHEMBL1084098 9.93 EC50 0.1175 Preclinical
CHEMBL1256240 9.82 EC50 0.15 Preclinical
CHEMBL1085100 9.52 EC50 0.3 Preclinical
CHEMBL5900571 9.52 IC50 0.3 Preclinical
CHEMBL1085103 9.4 EC50 0.4 Preclinical
Distribution

pChEMBL Value Distribution

135
5.0
172
5.5
198
6.0
297
6.5
552
7.0
474
7.5
320
8.0
119
8.5
42
9.0
7
9.5
pChEMBL
Assay Landscape

Assay Landscape

322
Total Assays
1,732
Tested Compounds
3
Assay Types
Binding — 267 assays, 1,732 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 186 405 6.4
single protein format 63 406 7.3
assay format 18 921 7.4
Functional — 49 assays, 183 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 37 171 6.2
assay format 12 12 6.6
ADME — 6 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 6 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine