Inhibitor of nuclear factor kappa-B kinase subunit beta · SINGLE PROTEIN · Mus musculus
This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.
Move to another high-traffic target or paste a specific ChEMBL target ID.
Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt O88351. Use UniProt O88351 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O88351 as the stable identity anchor, then attach disease evidence before program review.
Inhibitor of nuclear factor kappa-B kinase subunit beta
Review this target as Inhibitor of nuclear factor kappa-B kinase subunit beta, mapped to UniProt O88351. Sequence length is 757 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Inhibitor of nuclear factor kappa-B kinase subunit beta as ChEMBL target CHEMBL6012, mapped to UniProt O88351. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Inhibitor of nuclear factor kappa-B kinase subunit beta is the right protein anchor across sources, using UniProt O88351 as the stable mapping.
Jump to Protein ContextUse this block first when you need the strongest disease program and evidence level in one place.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Inhibitor of nuclear factor kappa-B kinase subunit beta |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | O88351 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Inhibitor of nuclear factor kappa-B kinase subunit beta |
| UniProt Accession | O88351 |
| Component Type | Protein |
| Sequence Length | 757 aa |
Inhibitor of nuclear factor kappa-B kinase subunit beta
Review this target as Inhibitor of nuclear factor kappa-B kinase subunit beta, mapped to UniProt O88351. Sequence length is 757 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3765499 | 6.3 | IC50 | 500.0 | Preclinical |
| CHEMBL360077 | 5.75 | IC50 | 1800.0 | Preclinical |
| CHEMBL2070413 | 5.7 | IC50 | 2000.0 | Preclinical |
| CHEMBL3765155 | 5.7 | IC50 | 2000.0 | Preclinical |
| CHEMBL3764369 | 5.52 | IC50 | 3000.0 | Preclinical |
| CHEMBL2070414 | 5.4 | IC50 | 4000.0 | Preclinical |
| CHEMBL3764354 | 5.4 | IC50 | 4000.0 | Preclinical |
| CHEMBL3764955 | 5.4 | IC50 | 4000.0 | Preclinical |
| CHEMBL3765189 | 5.4 | IC50 | 4000.0 | Preclinical |
| CHEMBL2070412 | 5.3 | IC50 | 5000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 30 | 14 | 5.1 |
| tissue-based format | 3 | 0 | — |
| assay format | 1 | 13 | 5.4 |