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Target Snapshot

CHEMBL6013 Target Snapshot

Ceramide glucosyltransferase · SINGLE PROTEIN · Mus musculus

89Compounds
13Assays
1Approved Drugs
93.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt O88693. Use UniProt O88693 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt O88693 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Ceramide glucosyltransferase as ChEMBL target CHEMBL6013, mapped to UniProt O88693. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Ceramide glucosyltransferase
SINGLE PROTEIN · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL6013
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
O88693
Ceramide glucosyltransferase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Ceramide glucosyltransferase is the right protein anchor across sources, using UniProt O88693 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCeramide glucosyltransferase
UniProt AccessionO88693
Component TypeProtein
Sequence Length394 aa

Ceramide glucosyltransferase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Ceramide glucosyltransferase, mapped to UniProt O88693. Sequence length is 394 aa.

Mapped IDO88693
Review nameCeramide glucosyltransferase
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5092.0
EC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5181454 8.74 IC50 1.8 Preclinical
CHEMBL5197585 8.43 IC50 3.7 Preclinical
CHEMBL5178033 8.26 IC50 5.5 Preclinical
CHEMBL5275403 7.77 IC50 17.0 Preclinical
CHEMBL5272946 7.68 IC50 21.0 Preclinical
CHEMBL1651637 7.3 IC50 50.0 Preclinical
CHEMBL1651638 7.3 IC50 50.0 Preclinical
CHEMBL5078078 7.29 IC50 51.0 Preclinical
CHEMBL1086996 7.0 IC50 100.0 Preclinical
CHEMBL1651633 7.0 IC50 100.0 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
4
5.5
2
6.0
7
6.5
8
7.0
2
7.5
2
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

13
Total Assays
34
Tested Compounds
2
Assay Types
Binding — 10 assays, 34 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 5 27 6.0
single protein format 3 7 7.0
assay format 2 0
Functional — 3 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 2 2 6.9
organism-based format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine