Segment polarity protein dishevelled homolog DVL-1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt O14640. Use UniProt O14640 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O14640 as the stable identity anchor, then attach disease evidence before program review.
Segment polarity protein dishevelled homolog DVL-1
Review this target as Segment polarity protein dishevelled homolog DVL-1, mapped to UniProt O14640. Sequence length is 695 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Segment polarity protein dishevelled homolog DVL-1 as ChEMBL target CHEMBL6027, mapped to UniProt O14640. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Segment polarity protein dishevelled homolog DVL-1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O14640 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Segment polarity protein dishevelled homolog DVL-1 |
| UniProt Accession | O14640 |
| Component Type | Protein |
| Sequence Length | 695 aa |
Segment polarity protein dishevelled homolog DVL-1
Review this target as Segment polarity protein dishevelled homolog DVL-1, mapped to UniProt O14640. Sequence length is 695 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3814692 | 6.73 | Kd | 186.0 | Preclinical |
| CHEMBL3814761 | 4.97 | Kd | 10600.0 | Preclinical |
| CHEMBL5170789 | 4.46 | Kd | 34500.0 | Preclinical |
| CHEMBL3814619 | 4.42 | Kd | 38300.0 | Preclinical |
| CHEMBL255779 | 4.31 | IC50 | 49000.0 | Preclinical |
| CHEMBL3814879 | 4.21 | Kd | 62400.0 | Preclinical |
| CHEMBL3814864 | 4.17 | Kd | 68400.0 | Preclinical |
| CHEMBL402939 | 4.11 | IC50 | 78000.0 | Preclinical |
| CHEMBL272948 | 4.01 | IC50 | 97000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 7 | 11 | 4.9 |
| cell-based format | 2 | 0 | — |
| single protein format | 1 | 2 | 4.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 6 | 4.1 |