Eukaryotic translation initiation factor 2-alpha kinase 3 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q9NZJ5. Use UniProt Q9NZJ5 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9NZJ5 as the stable identity anchor, then attach disease evidence before program review.
Eukaryotic translation initiation factor 2-alpha kinase 3
Review this target as Eukaryotic translation initiation factor 2-alpha kinase 3, mapped to UniProt Q9NZJ5. Sequence length is 1116 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Eukaryotic translation initiation factor 2-alpha kinase 3 as ChEMBL target CHEMBL6030, mapped to UniProt Q9NZJ5. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Eukaryotic translation initiation factor 2-alpha kinase 3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9NZJ5 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Eukaryotic translation initiation factor 2-alpha kinase 3 |
| UniProt Accession | Q9NZJ5 |
| Component Type | Protein |
| Sequence Length | 1116 aa |
Eukaryotic translation initiation factor 2-alpha kinase 3
Review this target as Eukaryotic translation initiation factor 2-alpha kinase 3, mapped to UniProt Q9NZJ5. Sequence length is 1116 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2171122 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL2171126 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL2171141 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL2171143 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL2171144 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL2171125 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL2171124 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL2171139 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL3355039 | 9.4 | IC50 | 0.3981 | Preclinical |
| CHEMBL2171123 | 9.3 | IC50 | 0.5 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 95 | 126 | 7.5 |
| cell-based format | 33 | 48 | 6.6 |
| subcellular format | 12 | 0 | — |
| assay format | 5 | 49 | 7.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 1 | 4.6 |