Thioredoxin reductase 1, cytoplasmic · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt O89049. Use UniProt O89049 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O89049 as the stable identity anchor, then attach disease evidence before program review.
Thioredoxin reductase 1, cytoplasmic
Review this target as Thioredoxin reductase 1, cytoplasmic, mapped to UniProt O89049. Sequence length is 499 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Thioredoxin reductase 1, cytoplasmic as ChEMBL target CHEMBL6035, mapped to UniProt O89049. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Thioredoxin reductase 1, cytoplasmic |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | O89049 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Thioredoxin reductase 1, cytoplasmic |
| UniProt Accession | O89049 |
| Component Type | Protein |
| Sequence Length | 499 aa |
Thioredoxin reductase 1, cytoplasmic
Review this target as Thioredoxin reductase 1, cytoplasmic, mapped to UniProt O89049. Sequence length is 499 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2035489 | 6.89 | IC50 | 130.0 | Preclinical |
| CHEMBL4792536 | 6.72 | IC50 | 190.0 | Preclinical |
| CHEMBL285848 | 6.57 | IC50 | 272.0 | Preclinical |
| CHEMBL2034987 | 6.55 | IC50 | 280.0 | Preclinical |
| CHEMBL2035491 | 6.5 | IC50 | 320.0 | Preclinical |
| CHEMBL2035460 | 6.46 | IC50 | 350.0 | Preclinical |
| CHEMBL2035484 | 6.24 | IC50 | 570.0 | Preclinical |
| CHEMBL4745896 | 6.23 | IC50 | 590.0 | Preclinical |
| CHEMBL4459518 | 6.22 | IC50 | 600.0 | Preclinical |
| CHEMBL11475 | 6.16 | IC50 | 700.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 23 | 23 | 5.0 |
| single protein format | 22 | 53 | 5.2 |
| tissue-based format | 1 | 33 | 5.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 5 | 0 | — |