Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL6066545 Target Snapshot

Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B · PROTEIN COMPLEX · Oryzias latipes

Back to Search Search this target Browse approvals Evidence Card
47Compounds
3Assays
1Approved Drugs
48.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Research home Demo workspace
Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P15206. Use UniProt P15206 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P15206 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B as ChEMBL target CHEMBL6066545, mapped to UniProt P15206. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B
PROTEIN COMPLEX · Oryzias latipes
As of 2026-09-14
ChEMBL target ID
CHEMBL6066545
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P15206
G2/mitotic-specific cyclin-B
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B is the right protein anchor across sources, using UniProt P15206 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B
Target TypePROTEIN COMPLEX
OrganismOryzias latipes
UniProtP15206
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelG2/mitotic-specific cyclin-B
UniProt AccessionP15206
Component TypeProtein
Sequence Length388 aa

G2/mitotic-specific cyclin-B

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B, mapped to UniProt P15206. ChEMBL maps the protein component as G2/mitotic-specific cyclin-B. Sequence length is 388 aa.

Mapped IDP15206
Review nameCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B
OrganismOryzias latipes
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC5048.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5946157 8.89 IC50 1.3 Preclinical
CHEMBL5825661 8.7 IC50 2.0 Preclinical
CHEMBL5760232 8.52 IC50 3.0 Preclinical
CHEMBL5955040 8.52 IC50 3.0 Preclinical
CHEMBL5803114 8.41 IC50 3.9 Preclinical
CHEMBL6002023 8.3 IC50 5.0 Preclinical
CHEMBL5961536 8.24 IC50 5.8 Preclinical
CHEMBL6058548 8.17 IC50 6.7 Preclinical
CHEMBL6043217 8.05 IC50 9.0 Preclinical
CHEMBL5774630 7.68 IC50 21.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
3
5.5
16
6.0
8
6.5
7
7.0
1
7.5
5
8.0
4
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

ABEMACICLIB
CHEMBL3301610
Approved 2017
Properties Compare Identifier
Assay Landscape

Assay Landscape

3
Total Assays
44
Tested Compounds
1
Assay Types
Binding — 3 assays, 44 compounds
BAO Format Assays Compounds Avg pChEMBL
protein complex format 3 44 6.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine