H-2 class II histocompatibility antigen gamma chain/Proto-oncogene tyrosine-protein kinase ROS · CHIMERIC PROTEIN · Mus musculus
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As of 2026-09-13Protein identity stays anchored to UniProt Q78DX7. Use UniProt Q78DX7 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q78DX7 as the stable identity anchor, then attach disease evidence before program review.
Proto-oncogene tyrosine-protein kinase ROS
Review this target as H-2 class II histocompatibility antigen gamma chain/Proto-oncogene tyrosine-protein kinase ROS, mapped to UniProt Q78DX7. ChEMBL maps the protein component as Proto-oncogene tyrosine-protein kinase ROS. Sequence length is 2340 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats H-2 class II histocompatibility antigen gamma chain/Proto-oncogene tyrosine-protein kinase ROS as ChEMBL target CHEMBL6066844, mapped to UniProt Q78DX7. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | H-2 class II histocompatibility antigen gamma chain/Proto-oncogene tyrosine-protein kinase ROS |
| Target Type | CHIMERIC PROTEIN |
| Organism | Mus musculus |
| UniProt | Q78DX7 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Proto-oncogene tyrosine-protein kinase ROS |
| UniProt Accession | Q78DX7 |
| Component Type | Protein |
| Sequence Length | 2340 aa |
Proto-oncogene tyrosine-protein kinase ROS
Review this target as H-2 class II histocompatibility antigen gamma chain/Proto-oncogene tyrosine-protein kinase ROS, mapped to UniProt Q78DX7. ChEMBL maps the protein component as Proto-oncogene tyrosine-protein kinase ROS. Sequence length is 2340 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5712062 | 9.64 | IC50 | 0.23 | Preclinical |
| CHEMBL2105717 | 8.82 | IC50 | 1.5 | Approved |
| CHEMBL1230609 | 8.42 | IC50 | 3.8 | Clinical |
| CHEMBL601719 | 8.41 | IC50 | 3.9 | Approved |
| CHEMBL2403108 | 7.15 | IC50 | 71.0 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 13 | 5 | 8.3 |