Use UniProt Q09161 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL6066853 Target Snapshot
Nuclear cap-binding protein subunit 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q09161. Use UniProt Q09161 as the stable identity anchor, then attach disease evidence before program review.
Nuclear cap-binding protein subunit 1
Review this target as Nuclear cap-binding protein subunit 1, mapped to UniProt Q09161. Sequence length is 790 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Nuclear cap-binding protein subunit 1 as ChEMBL target CHEMBL6066853, mapped to UniProt Q09161. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Nuclear cap-binding protein subunit 1 is the right protein anchor across sources, using UniProt Q09161 as the stable mapping.
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Open Review-ready CardBasic Information
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| Preferred Name | Nuclear cap-binding protein subunit 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q09161 |
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UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Nuclear cap-binding protein subunit 1 |
| UniProt Accession | Q09161 |
| Component Type | Protein |
| Sequence Length | 790 aa |
Nuclear cap-binding protein subunit 1
How to read this target
Review this target as Nuclear cap-binding protein subunit 1, mapped to UniProt Q09161. Sequence length is 790 aa.
Clinical Phase Distribution
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3752910 | 9.1 | Kd | 0.799 | Preclinical |
| CHEMBL1232461 | 6.94 | Kd | 114.0 | Clinical |
| CHEMBL1232461 | 6.77 | IC50 | 170.0 | Clinical |
| CHEMBL5653589 | 5.75 | Kd | 1778.93 | Preclinical |
pChEMBL Value Distribution
Assay Landscape
Binding — 8 assays, 3 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 8 | 3 | 7.1 |