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Target Snapshot

CHEMBL6066899 Target Snapshot

28S rRNA (cytosine(4447)-C(5))-methyltransferase · SINGLE PROTEIN · Homo sapiens

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2Compounds
1Assays
0Approved Drugs
2.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P46087. Use UniProt P46087 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P46087 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats 28S rRNA (cytosine(4447)-C(5))-methyltransferase as ChEMBL target CHEMBL6066899, mapped to UniProt P46087. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
28S rRNA (cytosine(4447)-C(5))-methyltransferase
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL6066899
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P46087
28S rRNA (cytosine(4447)-C(5))-methyltransferase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether 28S rRNA (cytosine(4447)-C(5))-methyltransferase is the right protein anchor across sources, using UniProt P46087 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred Name28S rRNA (cytosine(4447)-C(5))-methyltransferase
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP46087
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein Label28S rRNA (cytosine(4447)-C(5))-methyltransferase
UniProt AccessionP46087
Component TypeProtein
Sequence Length812 aa

28S rRNA (cytosine(4447)-C(5))-methyltransferase

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as 28S rRNA (cytosine(4447)-C(5))-methyltransferase, mapped to UniProt P46087. Sequence length is 812 aa.

Mapped IDP46087
Review name28S rRNA (cytosine(4447)-C(5))-methyltransferase
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

KD2.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3752910 9.69 Kd 0.204 Preclinical
CHEMBL5653589 6.44 Kd 366.34 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
1
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
1
9.5
pChEMBL
Assay Landscape

Assay Landscape

1
Total Assays
2
Tested Compounds
1
Assay Types
Binding — 1 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 2 8.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine