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Target Snapshot

CHEMBL6071 Target Snapshot

Lactate dehydrogenase · SINGLE PROTEIN · Plasmodium falciparum

15Compounds
2Assays
0Approved Drugs
15.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q0PJ46. Use UniProt Q0PJ46 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q0PJ46 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Lactate dehydrogenase as ChEMBL target CHEMBL6071, mapped to UniProt Q0PJ46. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Lactate dehydrogenase
SINGLE PROTEIN · Plasmodium falciparum
As of 2026-09-14
ChEMBL target ID
CHEMBL6071
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q0PJ46
L-lactate dehydrogenase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Lactate dehydrogenase is the right protein anchor across sources, using UniProt Q0PJ46 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelL-lactate dehydrogenase
UniProt AccessionQ0PJ46
Component TypeProtein
Sequence Length316 aa

L-lactate dehydrogenase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Lactate dehydrogenase, mapped to UniProt Q0PJ46. ChEMBL maps the protein component as L-lactate dehydrogenase. Sequence length is 316 aa.

Mapped IDQ0PJ46
Review nameLactate dehydrogenase
OrganismPlasmodium falciparum
Clinical Profile

Clinical Phase Distribution

1
Phase III
Assay Mix

Activity Type Distribution

IC5015.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1232973 6.85 IC50 140.0 Preclinical
CHEMBL1235045 6.19 IC50 650.0 Preclinical
CHEMBL1232960 5.96 IC50 1100.0 Preclinical
CHEMBL242020 5.76 IC50 1750.0 Preclinical
CHEMBL51483 5.58 IC50 2640.0 Clinical
CHEMBL242019 5.5 IC50 3130.0 Preclinical
CHEMBL390488 5.08 IC50 8250.0 Preclinical
CHEMBL5269776 4.8 IC50 16000.0 Preclinical
CHEMBL245025 4.06 IC50 87300.0 Preclinical
CHEMBL15976 4.03 IC50 92500.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
4
5.5
1
6.0
1
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

2
Total Assays
11
Tested Compounds
1
Assay Types
Binding — 2 assays, 11 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 2 11 5.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine