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Target Snapshot

CHEMBL6084 Target Snapshot

Acetylcholine-binding protein · SINGLE PROTEIN · Lymnaea stagnalis

186Compounds
22Assays
3Approved Drugs
215.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P58154. Use UniProt P58154 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P58154 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Acetylcholine-binding protein as ChEMBL target CHEMBL6084, mapped to UniProt P58154. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Acetylcholine-binding protein
SINGLE PROTEIN · Lymnaea stagnalis
As of 2026-09-13
ChEMBL target ID
CHEMBL6084
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P58154
Acetylcholine-binding protein
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Acetylcholine-binding protein is the right protein anchor across sources, using UniProt P58154 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAcetylcholine-binding protein
UniProt AccessionP58154
Component TypeProtein
Sequence Length229 aa

Acetylcholine-binding protein

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Acetylcholine-binding protein, mapped to UniProt P58154. Sequence length is 229 aa.

Mapped IDP58154
Review nameAcetylcholine-binding protein
OrganismLymnaea stagnalis
Clinical Profile

Clinical Phase Distribution

3
Approved
7
Phase II
Assay Mix

Activity Type Distribution

IC505.0
KI176.0
KD34.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL6623 9.52 Ki 0.3 Preclinical
CHEMBL1162395 9.4 Kd 0.4 Preclinical
CHEMBL1163383 9.1 Kd 0.8 Preclinical
CHEMBL1165604 9.1 Kd 0.8 Preclinical
CHEMBL4554047 9.07 Ki 0.86 Preclinical
CHEMBL4440256 8.64 Ki 2.27 Preclinical
CHEMBL4437999 8.47 Ki 3.39 Preclinical
CHEMBL4458658 8.46 Ki 3.47 Preclinical
CHEMBL4557873 8.28 Ki 5.3 Preclinical
CHEMBL4551353 8.28 Ki 5.22 Preclinical
Distribution

pChEMBL Value Distribution

21
5.0
25
5.5
36
6.0
26
6.5
23
7.0
26
7.5
8
8.0
1
8.5
4
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

NICOTINE
CHEMBL3
Approved 1984
Assay Landscape

Assay Landscape

22
Total Assays
152
Tested Compounds
1
Assay Types
Binding — 22 assays, 152 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 16 88 6.8
cell-based format 4 42 6.2
assay format 2 22 5.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine