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Target Snapshot

CHEMBL6100 Target Snapshot

Autoinducer 2-binding periplasmic protein LuxP · SINGLE PROTEIN · Vibrio harveyi

29Compounds
14Assays
0Approved Drugs
37.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P54300. Use UniProt P54300 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P54300 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Autoinducer 2-binding periplasmic protein LuxP as ChEMBL target CHEMBL6100, mapped to UniProt P54300. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Autoinducer 2-binding periplasmic protein LuxP
SINGLE PROTEIN · Vibrio harveyi
As of 2026-09-14
ChEMBL target ID
CHEMBL6100
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P54300
Autoinducer 2-binding periplasmic protein LuxP
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Autoinducer 2-binding periplasmic protein LuxP is the right protein anchor across sources, using UniProt P54300 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAutoinducer 2-binding periplasmic protein LuxP
UniProt AccessionP54300
Component TypeProtein
Sequence Length365 aa

Autoinducer 2-binding periplasmic protein LuxP

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Autoinducer 2-binding periplasmic protein LuxP, mapped to UniProt P54300. Sequence length is 365 aa.

Mapped IDP54300
Review nameAutoinducer 2-binding periplasmic protein LuxP
OrganismVibrio harveyi
Clinical Profile

Clinical Phase Distribution

1
Phase II
Assay Mix

Activity Type Distribution

IC5017.0
EC5020.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL193493 7.5 EC50 32.0 Preclinical
CHEMBL1939889 6.85 EC50 140.0 Preclinical
CHEMBL560745 6.24 EC50 580.0 Preclinical
CHEMBL539221 6.12 EC50 750.0 Preclinical
CHEMBL539143 6.0 EC50 1010.0 Preclinical
CHEMBL562281 5.87 EC50 1350.0 Preclinical
CHEMBL550518 5.82 EC50 1520.0 Preclinical
CHEMBL540164 5.74 EC50 1810.0 Preclinical
CHEMBL1939887 5.73 EC50 1870.0 Preclinical
CHEMBL307145 5.7 IC50 2000.0 Preclinical
Distribution

pChEMBL Value Distribution

4
5.0
7
5.5
4
6.0
2
6.5
1
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

14
Total Assays
25
Tested Compounds
2
Assay Types
Binding — 8 assays, 6 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 8 6 5.8
Functional — 6 assays, 25 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 6 25 5.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine