Neprilysin · SINGLE PROTEIN · Sus scrofa
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt P19621. Use UniProt P19621 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P19621 as the stable identity anchor, then attach disease evidence before program review.
Neprilysin
Review this target as Neprilysin, mapped to UniProt P19621. Sequence length is 26 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Neprilysin as ChEMBL target CHEMBL6107, mapped to UniProt P19621. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Neprilysin is the right protein anchor across sources, using UniProt P19621 as the stable mapping.
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| Preferred Name | Neprilysin |
| Target Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
| UniProt | P19621 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Neprilysin |
| UniProt Accession | P19621 |
| Component Type | Protein |
| Sequence Length | 26 aa |
Neprilysin
Review this target as Neprilysin, mapped to UniProt P19621. Sequence length is 26 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL10247 | 8.21 | IC50 | 6.2 | Preclinical |
| CHEMBL173287 | 7.39 | IC50 | 41.0 | Preclinical |
| CHEMBL367174 | 7.3 | IC50 | 50.0 | Preclinical |
| CHEMBL540674 | 7.1 | IC50 | 80.0 | Preclinical |
| CHEMBL551145 | 6.64 | IC50 | 230.0 | Preclinical |
| CHEMBL560685 | 6.52 | IC50 | 300.0 | Preclinical |
| CHEMBL560409 | 6.37 | IC50 | 430.0 | Preclinical |
| CHEMBL551622 | 6.24 | IC50 | 580.0 | Preclinical |
| CHEMBL558146 | 5.94 | IC50 | 1150.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 9 | 6.9 |