Thioredoxin glutathione reductase · SINGLE PROTEIN · Schistosoma mansoni
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As of 2026-09-14Protein identity stays anchored to UniProt Q962Y6. Use UniProt Q962Y6 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q962Y6 as the stable identity anchor, then attach disease evidence before program review.
thioredoxin-disulfide reductase
Review this target as Thioredoxin glutathione reductase, mapped to UniProt Q962Y6. ChEMBL maps the protein component as thioredoxin-disulfide reductase. Sequence length is 598 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Thioredoxin glutathione reductase as ChEMBL target CHEMBL6110, mapped to UniProt Q962Y6. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Thioredoxin glutathione reductase |
| Target Type | SINGLE PROTEIN |
| Organism | Schistosoma mansoni |
| UniProt | Q962Y6 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | thioredoxin-disulfide reductase |
| UniProt Accession | Q962Y6 |
| Component Type | Protein |
| Sequence Length | 598 aa |
thioredoxin-disulfide reductase
Review this target as Thioredoxin glutathione reductase, mapped to UniProt Q962Y6. ChEMBL maps the protein component as thioredoxin-disulfide reductase. Sequence length is 598 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3322287 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL570345 | 7.4 | IC50 | 40.0 | Preclinical |
| CHEMBL1439384 | 7.22 | IC50 | 60.0 | Preclinical |
| CHEMBL576265 | 7.2 | IC50 | 63.0 | Preclinical |
| CHEMBL3322292 | 7.08 | IC50 | 83.0 | Preclinical |
| CHEMBL1325877 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL567637 | 6.96 | IC50 | 110.0 | Preclinical |
| CHEMBL1486739 | 6.89 | IC50 | 130.0 | Preclinical |
| CHEMBL4846043 | 6.85 | IC50 | 140.0 | Preclinical |
| CHEMBL3322286 | 6.83 | IC50 | 148.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 11 | 51 | 5.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |