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Target Snapshot

CHEMBL6113 Target Snapshot

Phosphoethanolamine/phosphocholine phosphatase · SINGLE PROTEIN · Homo sapiens

72Compounds
3Assays
1Approved Drugs
96.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q8TCT1. Use UniProt Q8TCT1 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q8TCT1 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Phosphoethanolamine/phosphocholine phosphatase as ChEMBL target CHEMBL6113, mapped to UniProt Q8TCT1. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Phosphoethanolamine/phosphocholine phosphatase
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL6113
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q8TCT1
Phosphoethanolamine/phosphocholine phosphatase
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Phosphoethanolamine/phosphocholine phosphatase is the right protein anchor across sources, using UniProt Q8TCT1 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPhosphoethanolamine/phosphocholine phosphatase
UniProt AccessionQ8TCT1
Component TypeProtein
Sequence Length267 aa

Phosphoethanolamine/phosphocholine phosphatase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Phosphoethanolamine/phosphocholine phosphatase, mapped to UniProt Q8TCT1. Sequence length is 267 aa.

Mapped IDQ8TCT1
Review namePhosphoethanolamine/phosphocholine phosphatase
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase III
Assay Mix

Activity Type Distribution

IC5096.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1732623 7.63 IC50 23.3 Preclinical
CHEMBL1724427 7.46 IC50 34.8 Preclinical
CHEMBL1606007 7.14 IC50 72.5 Preclinical
CHEMBL1714665 7.0 IC50 100.0 Preclinical
CHEMBL51085 6.96 IC50 111.0 Clinical
CHEMBL1570441 6.86 IC50 139.0 Preclinical
CHEMBL1725457 6.72 IC50 192.5 Preclinical
CHEMBL1717022 6.63 IC50 233.0 Preclinical
CHEMBL1727796 6.6 IC50 252.0 Preclinical
CHEMBL1705022 6.45 IC50 359.0 Preclinical
Distribution

pChEMBL Value Distribution

22
5.0
24
5.5
25
6.0
6
6.5
3
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

LANSOPRAZOLE
CHEMBL480
Approved 1995
Assay Landscape

Assay Landscape

4
Total Assays
66
Tested Compounds
1
Assay Types
Binding — 4 assays, 66 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 4 66 5.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine