Solute carrier family 22 member 12 · SINGLE PROTEIN · Homo sapiens
This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.
Move to another high-traffic target or paste a specific ChEMBL target ID.
Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Solute carrier family 22 member 12 shows approved-linked disease relevance led by gout. 5 more disease programs remain visible in the same review block. 7 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q96S37. Start with gout, then reuse UniProt Q96S37 as the stable protein anchor across project notes and exports.
Start with gout, then reuse UniProt Q96S37 as the stable protein anchor across project notes and exports.
Solute carrier family 22 member 12 shows approved-linked disease relevance led by gout. 5 more disease programs remain visible in the same review block. 7 linked drugs remain visible in the same block.
Start review with gout because it currently carries approved-linked support. Linked drugs include ARHALOFENATE, BENZBROMARONE, DOTINURAD, LESINURAD. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxySolute carrier family 22 member 12
Review this target as Solute carrier family 22 member 12, mapped to UniProt Q96S37. Sequence length is 553 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Solute carrier family 22 member 12 as ChEMBL target CHEMBL6120, mapped to UniProt Q96S37. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Solute carrier family 22 member 12 is the right protein anchor across sources, using UniProt Q96S37 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why gout is currently framed as approved-linked support. It currently carries 7 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Solute carrier family 22 member 12 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q96S37 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Solute carrier family 22 member 12 |
| UniProt Accession | Q96S37 |
| Component Type | Protein |
| Sequence Length | 553 aa |
Solute carrier family 22 member 12
Review this target as Solute carrier family 22 member 12, mapped to UniProt Q96S37. Sequence length is 553 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Solute carrier family 22 member 12 shows approved-linked disease relevance led by gout. 5 more disease programs remain visible in the same review block.
Start review with gout because it currently carries approved-linked support. Linked drugs include ARHALOFENATE, BENZBROMARONE, DOTINURAD, LESINURAD. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3688197 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL3688190 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL4087516 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL3688192 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL5414132 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL5399348 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL3683365 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL3971610 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL3688188 | 8.1 | IC50 | 8.0 | Preclinical |
| CHEMBL5759161 | 8.1 | IC50 | 8.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 59 | 409 | 6.1 |
| single protein format | 18 | 37 | 6.4 |
| assay format | 17 | 438 | 6.4 |
| tissue-based format | 3 | 19 | 5.0 |