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Target Snapshot

CHEMBL612263 Target Snapshot

HCT-15 · CELL-LINE · Homo sapiens

46,949Compounds
1,653Assays
37Approved Drugs
3,154.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats HCT-15 as ChEMBL target CHEMBL612263. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
HCT-15
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL612263
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether HCT-15 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHCT-15
UniProt AccessionN/A

HCT-15

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as HCT-15.

Review nameHCT-15
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

37
Approved
16
Phase III
19
Phase II
6
Phase I
Assay Mix

Activity Type Distribution

IC503,128.0
EC5026.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1288631 10.0 IC50 0.1 Preclinical
CHEMBL1288636 10.0 IC50 0.1 Preclinical
CHEMBL1288637 10.0 IC50 0.1 Preclinical
CHEMBL378080 9.89 IC50 0.13 Preclinical
CHEMBL1683550 9.85 IC50 0.14 Preclinical
CHEMBL1683602 9.82 IC50 0.15 Preclinical
CHEMBL1683546 9.8 IC50 0.16 Preclinical
CHEMBL1683605 9.77 IC50 0.17 Preclinical
CHEMBL1683556 9.72 IC50 0.19 Preclinical
CHEMBL1683529 9.7 IC50 0.2 Preclinical
Distribution

pChEMBL Value Distribution

573
5.0
452
5.5
241
6.0
121
6.5
134
7.0
71
7.5
41
8.0
21
8.5
27
9.0
16
9.5
pChEMBL
Approved Drugs

Approved Drugs

MIDOSTAURIN
CHEMBL608533
Approved 2017
ERIBULIN
CHEMBL1683590
Approved 2010
GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
PACLITAXEL
CHEMBL428647
Approved 1992
PODOFILOX
CHEMBL61
Approved 1990
AMSACRINE
CHEMBL43
Approved 1987
ETOPOSIDE
CHEMBL44657
Approved 1983
MITOMYCIN
CHEMBL105
Approved 1981
DOXORUBICIN
CHEMBL53463
Approved 1974
DOXORUBICIN HYDROCHLORIDE
CHEMBL359744
Approved 1974
FLOXURIDINE
CHEMBL917
Approved 1970
VINBLASTINE
CHEMBL159
Approved 1965
FLUOROURACIL
CHEMBL185
Approved 1962
COLCHICINE
CHEMBL107
Approved 1961
METHOTREXATE
CHEMBL34259
Approved 1953
Assay Landscape

Assay Landscape

1,656
Total Assays
2,048
Tested Compounds
2
Assay Types
Functional — 1,641 assays, 2,048 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1,587 2,048 5.7
organism-based format 54 0
ADME — 15 assays, 18 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 15 18 6.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine