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Target Snapshot

CHEMBL612267 Target Snapshot

L929 · CELL-LINE · Mus musculus

Back to Search Search this target Browse approvals Evidence Card
3,301Compounds
576Assays
15Approved Drugs
2,461.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats L929 as ChEMBL target CHEMBL612267. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
L929
CELL-LINE · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL612267
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether L929 still has a stable protein naming contract across sources.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameL929
Target TypeCELL-LINE
OrganismMus musculus
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelL929
UniProt AccessionN/A

L929

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as L929.

Review nameL929
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

15
Approved
4
Phase III
2
Phase II
4
Phase I
Assay Mix

Activity Type Distribution

IC502,180.0
EC50281.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5595640 10.99 EC50 0.0102 Preclinical
CHEMBL2441342 10.0 IC50 0.1 Preclinical
CHEMBL2171124 9.4 IC50 0.4 Preclinical
CHEMBL272733 9.37 IC50 0.43 Preclinical
CHEMBL5561992 9.32 EC50 0.48 Preclinical
CHEMBL94657 9.12 IC50 0.75 Clinical
CHEMBL241106 9.09 IC50 0.81 Preclinical
CHEMBL4281823 9.0 EC50 0.999 Preclinical
CHEMBL4521353 9.0 IC50 1.0 Preclinical
CHEMBL5175478 9.0 IC50 1.0 Preclinical
Distribution

pChEMBL Value Distribution

136
5.0
103
5.5
41
6.0
32
6.5
19
7.0
22
7.5
19
8.0
25
8.5
9
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

GEMCITABINE
CHEMBL888
Approved 1996
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
ETOPOSIDE
CHEMBL44657
Approved 1983
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
COLCHICINE
CHEMBL107
Approved 1961
Properties Compare Identifier
Assay Landscape

Assay Landscape

576
Total Assays
383
Tested Compounds
4
Assay Types
ADME — 236 assays, 383 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 236 383 5.0
Functional — 207 assays, 224 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 202 224 6.4
organism-based format 5 0 —
Toxicity — 129 assays, 166 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 129 166 5.1
Unassigned — 4 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 4 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine