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Target Snapshot

CHEMBL612270 Target Snapshot

M4Beu cell line · CELL-LINE · Homo sapiens

47Compounds
10Assays
2Approved Drugs
23.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats M4Beu cell line as ChEMBL target CHEMBL612270. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
M4Beu cell line
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL612270
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether M4Beu cell line still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelM4Beu cell line
UniProt AccessionN/A

M4Beu cell line

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as M4Beu cell line.

Review nameM4Beu cell line
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Approved
Assay Mix

Activity Type Distribution

IC5023.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL852 5.92 IC50 1200.0 Approved
CHEMBL411066 5.82 IC50 1500.0 Preclinical
CHEMBL4208248 5.52 IC50 3000.0 Preclinical
CHEMBL515 5.29 IC50 5100.0 Approved
CHEMBL68110 5.29 IC50 5100.0 Preclinical
CHEMBL4202444 5.22 IC50 6000.0 Preclinical
CHEMBL501118 5.17 IC50 6800.0 Preclinical
CHEMBL500328 5.16 IC50 7000.0 Preclinical
CHEMBL4218190 4.92 IC50 12000.0 Preclinical
CHEMBL4203376 4.86 IC50 13800.0 Preclinical
Distribution

pChEMBL Value Distribution

5
5.0
3
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

10
Total Assays
17
Tested Compounds
2
Assay Types
Functional — 9 assays, 17 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 9 17 5.0
ADME — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine