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Target Snapshot

CHEMBL612359 Target Snapshot

Human immunodeficiency virus 3 · ORGANISM · Human immunodeficiency virus 3

102Compounds
11Assays
1Approved Drugs
132.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

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Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Human immunodeficiency virus 3 as ChEMBL target CHEMBL612359. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Human immunodeficiency virus 3
ORGANISM · Human immunodeficiency virus 3
As of 2026-09-14
ChEMBL target ID
CHEMBL612359
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Human immunodeficiency virus 3 still has a stable protein naming contract across sources.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHuman immunodeficiency virus 3
UniProt AccessionN/A

Human immunodeficiency virus 3

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Human immunodeficiency virus 3.

Review nameHuman immunodeficiency virus 3
OrganismHuman immunodeficiency virus 3
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5024.0
EC50108.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL140665 10.48 EC50 0.033 Preclinical
CHEMBL435294 9.49 EC50 0.32 Preclinical
CHEMBL139532 9.37 EC50 0.425 Preclinical
CHEMBL141371 9.19 EC50 0.65 Preclinical
CHEMBL361580 9.0 EC50 0.99 Preclinical
CHEMBL138969 8.92 EC50 1.2 Preclinical
CHEMBL41477 8.89 EC50 1.3 Preclinical
CHEMBL361146 8.51 EC50 3.1 Preclinical
CHEMBL137838 8.5 EC50 3.17 Preclinical
CHEMBL365717 8.24 EC50 5.7 Preclinical
Distribution

pChEMBL Value Distribution

22
5.0
35
5.5
21
6.0
3
6.5
5
7.0
3
7.5
4
8.0
4
8.5
4
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

ZIDOVUDINE
CHEMBL129
Approved 1987
Assay Landscape

Assay Landscape

11
Total Assays
101
Tested Compounds
1
Assay Types
Functional — 11 assays, 101 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 11 101 6.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine