Anti-estrogen binding site (AEBS) · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q15125. Use UniProt Q15125 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q15125 as the stable identity anchor, then attach disease evidence before program review.
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
Review this target as Anti-estrogen binding site (AEBS), mapped to UniProt Q15125. ChEMBL maps the protein component as 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase. Sequence length is 230 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Anti-estrogen binding site (AEBS) as ChEMBL target CHEMBL612409, mapped to UniProt Q15125. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Anti-estrogen binding site (AEBS) is the right protein anchor across sources, using UniProt Q15125 as the stable mapping.
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| Preferred Name | Anti-estrogen binding site (AEBS) |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | Q15125 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase |
| UniProt Accession | Q15125 |
| Component Type | Protein |
| Sequence Length | 230 aa |
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
Review this target as Anti-estrogen binding site (AEBS), mapped to UniProt Q15125. ChEMBL maps the protein component as 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase. Sequence length is 230 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL83 | 9.0 | Kd | 1.0 | Approved |
| CHEMBL83 | 7.92 | IC50 | 12.0 | Approved |
| CHEMBL955 | 7.66 | IC50 | 22.0 | Preclinical |
| CHEMBL222694 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL292185 | 7.5 | IC50 | 32.0 | Preclinical |
| CHEMBL266892 | 7.3 | IC50 | 50.0 | Preclinical |
| CHEMBL53463 | 6.82 | IC50 | 150.0 | Approved |
| CHEMBL342394 | 6.4 | IC50 | 400.0 | Preclinical |
| CHEMBL455316 | 6.22 | IC50 | 600.0 | Preclinical |
| CHEMBL464782 | 6.22 | IC50 | 600.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 14 | 3 | 6.8 |
| tissue-based format | 5 | 0 | — |
| assay format | 4 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 5 | 3 | 8.0 |
| cell-based format | 3 | 0 | — |
| assay format | 2 | 8 | 5.7 |
| tissue-based format | 2 | 0 | — |