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Target Snapshot

CHEMBL612422 Target Snapshot

Splenocyte · CELL-LINE · Mus musculus

Back to Search Search this target Browse approvals Evidence Card
832Compounds
357Assays
8Approved Drugs
512.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Splenocyte as ChEMBL target CHEMBL612422. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Splenocyte
CELL-LINE · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL612422
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Splenocyte still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSplenocyte
Target TypeCELL-LINE
OrganismMus musculus
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSplenocyte
UniProt AccessionN/A

Splenocyte

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Splenocyte.

Review nameSplenocyte
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

8
Approved
1
Phase III
2
Phase II
Assay Mix

Activity Type Distribution

IC50492.0
EC5020.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2442465 9.68 IC50 0.21 Preclinical
CHEMBL481611 9.0 IC50 1.0 Clinical
CHEMBL384467 9.0 IC50 1.0 Approved
CHEMBL193240 8.92 IC50 1.2 Approved
CHEMBL4287849 8.7 IC50 2.0 Preclinical
CHEMBL2442472 8.52 IC50 3.0 Preclinical
CHEMBL1916891 8.47 IC50 3.41 Preclinical
CHEMBL2442462 8.42 IC50 3.8 Preclinical
CHEMBL564976 8.4 IC50 4.0 Preclinical
CHEMBL561464 8.4 IC50 4.0 Preclinical
Distribution

pChEMBL Value Distribution

71
5.0
31
5.5
24
6.0
16
6.5
33
7.0
13
7.5
15
8.0
3
8.5
2
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

ROFLUMILAST
CHEMBL193240
Approved 2010
Properties Compare Identifier
MYCOPHENOLATE MOFETIL
CHEMBL1456
Approved 1995
Properties Compare Identifier
CYCLOSPORINE
CHEMBL160
Approved 1983
Properties Compare Identifier
DEXAMETHASONE
CHEMBL384467
Approved 1958
Properties Compare Identifier
Assay Landscape

Assay Landscape

357
Total Assays
224
Tested Compounds
4
Assay Types
Functional — 316 assays, 224 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 293 224 5.7
organism-based format 23 0 —
ADME — 26 assays, 6 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 26 6 5.5
Toxicity — 13 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 13 0 —
Unassigned — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine