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Target Snapshot

CHEMBL612446 Target Snapshot

UACC-903 · CELL-LINE · Homo sapiens

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101Compounds
86Assays
3Approved Drugs
151.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats UACC-903 as ChEMBL target CHEMBL612446. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
UACC-903
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL612446
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether UACC-903 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameUACC-903
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelUACC-903
UniProt AccessionN/A

UACC-903

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as UACC-903.

Review nameUACC-903
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

3
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC50151.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL43482 6.3 IC50 500.0 Clinical
CHEMBL2017171 5.89 IC50 1290.0 Preclinical
CHEMBL2018419 5.86 IC50 1390.0 Preclinical
CHEMBL378544 5.78 IC50 1650.0 Approved
CHEMBL4084498 5.77 IC50 1700.0 Preclinical
CHEMBL1834926 5.69 IC50 2060.0 Preclinical
CHEMBL1834929 5.65 IC50 2230.0 Preclinical
CHEMBL4160982 5.64 IC50 2300.0 Preclinical
CHEMBL1834928 5.58 IC50 2640.0 Preclinical
CHEMBL1229517 5.57 IC50 2700.0 Approved
Distribution

pChEMBL Value Distribution

49
5.0
18
5.5
2
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

86
Total Assays
84
Tested Compounds
1
Assay Types
Functional — 86 assays, 84 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 79 84 5.1
organism-based format 7 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine