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Target Snapshot

CHEMBL612543 Target Snapshot

SNB-78 · CELL-LINE · Homo sapiens

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12,991Compounds
54Assays
1Approved Drugs
37.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats SNB-78 as ChEMBL target CHEMBL612543. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
SNB-78
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL612543
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether SNB-78 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSNB-78
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSNB-78
UniProt AccessionN/A

SNB-78

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as SNB-78.

Review nameSNB-78
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5033.0
EC504.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1956190 6.15 IC50 710.0 Preclinical
CHEMBL38761 5.22 IC50 6000.0 Preclinical
CHEMBL368036 5.04 EC50 9100.0 Preclinical
CHEMBL187822 5.0 IC50 10010.0 Preclinical
CHEMBL61998 4.86 IC50 13780.0 Preclinical
CHEMBL370537 4.85 IC50 14040.0 Preclinical
CHEMBL98 4.8 EC50 16000.0 Approved
CHEMBL276600 4.78 IC50 16730.0 Preclinical
CHEMBL187875 4.68 IC50 21030.0 Preclinical
CHEMBL187451 4.66 IC50 22040.0 Preclinical
Distribution

pChEMBL Value Distribution

4
5.0
0
5.5
1
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

54
Total Assays
18
Tested Compounds
1
Assay Types
Functional — 54 assays, 18 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 54 18 4.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine