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Target Snapshot

CHEMBL612546 Target Snapshot

Molecular identity unknown · UNKNOWN

7,797Compounds
9,781Assays
28Approved Drugs
2,280.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Molecular identity unknown as ChEMBL target CHEMBL612546. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Molecular identity unknown
UNKNOWN
As of 2026-09-13
ChEMBL target ID
CHEMBL612546
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Molecular identity unknown still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMolecular identity unknown
UniProt AccessionN/A

Molecular identity unknown

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Molecular identity unknown.

Review nameMolecular identity unknown
Clinical Profile

Clinical Phase Distribution

28
Approved
9
Phase III
14
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC501,585.0
KI46.0
EC50649.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3675442 10.1 IC50 0.08 Preclinical
CHEMBL147862 10.0 EC50 0.1 Preclinical
CHEMBL344738 10.0 EC50 0.1 Preclinical
CHEMBL1910998 9.74 IC50 0.18 Preclinical
CHEMBL3114260 9.64 IC50 0.23 Preclinical
CHEMBL3114248 9.55 IC50 0.28 Preclinical
CHEMBL3114250 9.54 IC50 0.29 Preclinical
CHEMBL475534 9.5 EC50 0.3162 Clinical
CHEMBL3114425 9.47 IC50 0.34 Preclinical
CHEMBL3310722 9.46 IC50 0.35 Preclinical
Distribution

pChEMBL Value Distribution

286
5.0
247
5.5
230
6.0
156
6.5
145
7.0
109
7.5
75
8.0
80
8.5
40
9.0
6
9.5
pChEMBL
Approved Drugs

Approved Drugs

SONIDEGIB
CHEMBL2105737
Approved 2015
OSIMERTINIB
CHEMBL3353410
Approved 2015
BOSUTINIB
CHEMBL288441
Approved 2012
VISMODEGIB
CHEMBL473417
Approved 2012
NILOTINIB
CHEMBL255863
Approved 2007
POSACONAZOLE
CHEMBL1397
Approved 2005
IMATINIB
CHEMBL941
Approved 2001
SUMATRIPTAN
CHEMBL128
Approved 1992
PACLITAXEL
CHEMBL428647
Approved 1992
ITRACONAZOLE
CHEMBL64391
Approved 1992
ISOSORBIDE DINITRATE
CHEMBL6622
Approved 1986
PYRVINIUM
CHEMBL1201303
Approved 1982
NICLOSAMIDE
CHEMBL1448
Approved 1982
NIACIN
CHEMBL573
Approved 1982
NITROGLYCERIN
CHEMBL730
Approved 1981
VERAPAMIL
CHEMBL6966
Approved 1981
VINCRISTINE
CHEMBL90555
Approved 1963
COLCHICINE
CHEMBL107
Approved 1961
METHOTREXATE
CHEMBL34259
Approved 1953
Assay Landscape

Assay Landscape

9,806
Total Assays
917
Tested Compounds
5
Assay Types
Functional — 4,711 assays, 536 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3,803 265 6.3
assay format 719 227 5.9
organism-based format 153 0
tissue-based format 27 42 5.8
mitochondrion format 8 1 6.1
microsome format 1 1 4.6
Binding — 4,409 assays, 917 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3,860 598 6.7
assay format 536 307 5.3
cell-free format 5 0
cell membrane format 4 0
mitochondrion format 3 0
tissue-based format 1 12 4.6
ADME — 657 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-free format 435 0
organism-based format 155 0
tissue-based format 55 0
assay format 10 0
cell-based format 2 1 7.5
Toxicity — 28 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 13 0
tissue-based format 9 0
assay format 4 0
cell-free format 2 0
Unassigned — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine