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Target Snapshot

CHEMBL612598 Target Snapshot

KHOS/NP · CELL-LINE · Homo sapiens

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41Compounds
23Assays
1Approved Drugs
34.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats KHOS/NP as ChEMBL target CHEMBL612598. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
KHOS/NP
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL612598
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether KHOS/NP still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameKHOS/NP
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelKHOS/NP
UniProt AccessionN/A

KHOS/NP

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as KHOS/NP.

Review nameKHOS/NP
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5034.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL198075 8.0 IC50 10.0 Preclinical
CHEMBL4873815 5.51 IC50 3060.0 Preclinical
CHEMBL4878473 5.44 IC50 3610.0 Preclinical
CHEMBL4877032 5.43 IC50 3670.0 Preclinical
CHEMBL4868266 5.41 IC50 3890.0 Preclinical
CHEMBL4873154 5.35 IC50 4460.0 Preclinical
CHEMBL4859898 5.3 IC50 5010.0 Preclinical
CHEMBL4847466 5.26 IC50 5460.0 Preclinical
CHEMBL5555717 5.21 IC50 6200.0 Preclinical
CHEMBL3263773 5.19 IC50 6500.0 Preclinical
Distribution

pChEMBL Value Distribution

11
5.0
1
5.5
0
6.0
0
6.5
0
7.0
0
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

23
Total Assays
27
Tested Compounds
1
Assay Types
Functional — 23 assays, 27 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 19 27 5.1
organism-based format 4 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine