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Target Snapshot

CHEMBL612708 Target Snapshot

GTL 16 cell line · CELL-LINE · Homo sapiens

32Compounds
24Assays
1Approved Drugs
31.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats GTL 16 cell line as ChEMBL target CHEMBL612708. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
GTL 16 cell line
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL612708
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether GTL 16 cell line still has a stable protein naming contract across sources.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGTL 16 cell line
UniProt AccessionN/A

GTL 16 cell line

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as GTL 16 cell line.

Review nameGTL 16 cell line
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
2
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC5031.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2001019 7.92 IC50 12.0 Preclinical
CHEMBL460702 7.0 IC50 100.0 Clinical
CHEMBL575448 6.7 IC50 200.0 Clinical
CHEMBL185 6.08 IC50 840.0 Approved
CHEMBL5268484 5.7 IC50 2000.0 Preclinical
CHEMBL5203654 5.2 IC50 6370.0 Preclinical
CHEMBL5200094 5.13 IC50 7410.0 Preclinical
CHEMBL5171844 5.12 IC50 7520.0 Preclinical
CHEMBL5170054 5.04 IC50 9140.0 Preclinical
CHEMBL5196420 5.02 IC50 9640.0 Preclinical
Distribution

pChEMBL Value Distribution

5
5.0
1
5.5
1
6.0
1
6.5
1
7.0
2
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

FLUOROURACIL
CHEMBL185
Approved 1962
Assay Landscape

Assay Landscape

24
Total Assays
30
Tested Compounds
1
Assay Types
Functional — 24 assays, 30 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 17 0
cell-based format 7 30 5.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine