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Target Snapshot

CHEMBL612793 Target Snapshot

Leishmania guyanensis · ORGANISM · Leishmania guyanensis

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65Compounds
13Assays
2Approved Drugs
72.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Leishmania guyanensis as ChEMBL target CHEMBL612793. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Leishmania guyanensis
ORGANISM · Leishmania guyanensis
As of 2026-09-14
ChEMBL target ID
CHEMBL612793
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Leishmania guyanensis still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameLeishmania guyanensis
Target TypeORGANISM
OrganismLeishmania guyanensis
ChEMBL ↗ NCBI Taxonomy ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelLeishmania guyanensis
UniProt AccessionN/A

Leishmania guyanensis

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Leishmania guyanensis.

Review nameLeishmania guyanensis
OrganismLeishmania guyanensis
Clinical Profile

Clinical Phase Distribution

2
Approved
Assay Mix

Activity Type Distribution

IC5072.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL55 6.05 IC50 900.0 Approved
CHEMBL4551488 5.89 IC50 1300.0 Preclinical
CHEMBL3085906 5.37 IC50 4300.0 Preclinical
CHEMBL125 5.3 IC50 5000.0 Approved
CHEMBL4435634 5.26 IC50 5500.0 Preclinical
CHEMBL4582361 5.23 IC50 5900.0 Preclinical
CHEMBL3085903 5.14 IC50 7200.0 Preclinical
CHEMBL3343778 5.07 IC50 8600.0 Preclinical
CHEMBL3085891 4.98 IC50 10400.0 Preclinical
CHEMBL197310 4.9 IC50 12500.0 Preclinical
Distribution

pChEMBL Value Distribution

10
5.0
1
5.5
1
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PENTAMIDINE
CHEMBL55
Approved 1984
Properties Compare Identifier
Assay Landscape

Assay Landscape

17
Total Assays
48
Tested Compounds
1
Assay Types
Functional — 17 assays, 48 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 16 43 4.7
assay format 1 5 4.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine