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Target Snapshot

CHEMBL612880 Target Snapshot

Leishmania mexicana · ORGANISM · Leishmania mexicana

Back to Search Search this target Browse approvals Evidence Card
837Compounds
141Assays
10Approved Drugs
686.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Leishmania mexicana as ChEMBL target CHEMBL612880. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Leishmania mexicana
ORGANISM · Leishmania mexicana
As of 2026-09-13
ChEMBL target ID
CHEMBL612880
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Leishmania mexicana still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameLeishmania mexicana
Target TypeORGANISM
OrganismLeishmania mexicana
ChEMBL ↗ NCBI Taxonomy ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelLeishmania mexicana
UniProt AccessionN/A

Leishmania mexicana

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Leishmania mexicana.

Review nameLeishmania mexicana
OrganismLeishmania mexicana
Clinical Profile

Clinical Phase Distribution

10
Approved
2
Phase III
2
Phase II
Assay Mix

Activity Type Distribution

IC50344.0
EC50342.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL561057 8.0 IC50 10.0 Clinical
CHEMBL5549773 7.95 EC50 11.3 Preclinical
CHEMBL5542939 7.8 EC50 15.8 Preclinical
CHEMBL5562085 7.79 EC50 16.2 Preclinical
CHEMBL5559625 7.73 EC50 18.8 Preclinical
CHEMBL5568465 7.65 EC50 22.6 Preclinical
CHEMBL5558128 7.62 EC50 23.8 Preclinical
CHEMBL7668 7.52 IC50 30.0 Preclinical
CHEMBL5531951 7.5 EC50 32.0 Preclinical
CHEMBL5563339 7.5 EC50 31.4 Preclinical
Distribution

pChEMBL Value Distribution

51
5.0
51
5.5
68
6.0
27
6.5
41
7.0
10
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PENTAMIDINE
CHEMBL55
Approved 1984
Properties Compare Identifier
AMPHOTERICIN B
CHEMBL267345
Approved 1964
Properties Compare Identifier
Assay Landscape

Assay Landscape

143
Total Assays
331
Tested Compounds
1
Assay Types
Functional — 143 assays, 331 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 133 297 5.8
assay format 10 34 4.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine