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Target Snapshot

CHEMBL612881 Target Snapshot

Leishmania tropica · ORGANISM · Leishmania tropica

Back to Search Search this target Browse approvals Evidence Card
206Compounds
82Assays
4Approved Drugs
188.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Leishmania tropica as ChEMBL target CHEMBL612881. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Leishmania tropica
ORGANISM · Leishmania tropica
As of 2026-09-13
ChEMBL target ID
CHEMBL612881
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Leishmania tropica still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameLeishmania tropica
Target TypeORGANISM
OrganismLeishmania tropica
ChEMBL ↗ NCBI Taxonomy ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelLeishmania tropica
UniProt AccessionN/A

Leishmania tropica

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Leishmania tropica.

Review nameLeishmania tropica
OrganismLeishmania tropica
Clinical Profile

Clinical Phase Distribution

4
Approved
Assay Mix

Activity Type Distribution

IC50183.0
EC505.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5565124 7.4 IC50 40.0 Preclinical
CHEMBL267345 7.05 IC50 90.0 Approved
CHEMBL5429036 7.0 IC50 100.0 Preclinical
CHEMBL3356387 6.92 IC50 120.0 Preclinical
CHEMBL3356386 6.66 IC50 220.0 Preclinical
CHEMBL3356390 6.62 IC50 240.0 Preclinical
CHEMBL4080629 6.52 IC50 300.0 Preclinical
CHEMBL4869051 6.51 IC50 310.0 Preclinical
CHEMBL3356389 6.48 IC50 330.0 Preclinical
CHEMBL3356394 6.47 IC50 340.0 Preclinical
Distribution

pChEMBL Value Distribution

18
5.0
30
5.5
24
6.0
10
6.5
5
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

AMPHOTERICIN B
CHEMBL267345
Approved 1964
Properties Compare Identifier
Assay Landscape

Assay Landscape

82
Total Assays
92
Tested Compounds
2
Assay Types
Functional — 80 assays, 92 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 77 89 5.7
assay format 3 3 6.0
ADME — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 2 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine