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Target Snapshot

CHEMBL612927 Target Snapshot

Mammalian orthoreovirus 1 · ORGANISM · Mammalian orthoreovirus 1

1,418Compounds
105Assays
3Approved Drugs
578.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

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Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Mammalian orthoreovirus 1 as ChEMBL target CHEMBL612927. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Mammalian orthoreovirus 1
ORGANISM · Mammalian orthoreovirus 1
As of 2026-09-13
ChEMBL target ID
CHEMBL612927
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Mammalian orthoreovirus 1 still has a stable protein naming contract across sources.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMammalian orthoreovirus 1
UniProt AccessionN/A

Mammalian orthoreovirus 1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Mammalian orthoreovirus 1.

Review nameMammalian orthoreovirus 1
OrganismMammalian orthoreovirus 1
Clinical Profile

Clinical Phase Distribution

3
Approved
Assay Mix

Activity Type Distribution

IC5014.0
EC50564.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2312734 5.8 EC50 1600.0 Preclinical
CHEMBL2312736 5.8 EC50 1600.0 Preclinical
CHEMBL866 5.75 EC50 1800.0 Approved
CHEMBL418899 5.72 EC50 1900.0 Preclinical
CHEMBL268088 5.68 EC50 2100.0 Preclinical
CHEMBL4449670 5.51 EC50 3100.0 Preclinical
CHEMBL4463583 5.51 EC50 3100.0 Preclinical
CHEMBL92583 5.42 EC50 3800.0 Preclinical
CHEMBL2312735 5.4 EC50 4000.0 Preclinical
CHEMBL36 5.27 EC50 5400.0 Approved
Distribution

pChEMBL Value Distribution

8
5.0
9
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

105
Total Assays
35
Tested Compounds
1
Assay Types
Functional — 105 assays, 35 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 102 28 4.8
assay format 3 7 5.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine