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Target Snapshot

CHEMBL613011 Target Snapshot

Plasmodium knowlesi · ORGANISM · Plasmodium knowlesi

Back to Search Search this target Browse approvals Evidence Card
32Compounds
12Assays
2Approved Drugs
29.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Plasmodium knowlesi as ChEMBL target CHEMBL613011. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Plasmodium knowlesi
ORGANISM · Plasmodium knowlesi
As of 2026-09-13
ChEMBL target ID
CHEMBL613011
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Plasmodium knowlesi still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NamePlasmodium knowlesi
Target TypeORGANISM
OrganismPlasmodium knowlesi
ChEMBL ↗ NCBI Taxonomy ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPlasmodium knowlesi
UniProt AccessionN/A

Plasmodium knowlesi

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Plasmodium knowlesi.

Review namePlasmodium knowlesi
OrganismPlasmodium knowlesi
Clinical Profile

Clinical Phase Distribution

2
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC5017.0
EC5012.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4852828 8.21 IC50 6.1 Preclinical
CHEMBL76 8.0 EC50 10.0 Approved
CHEMBL76 8.0 IC50 10.0 Approved
CHEMBL3291280 7.55 IC50 28.0 Preclinical
CHEMBL5592130 7.43 EC50 37.0 Preclinical
CHEMBL172 7.4 IC50 40.0 Preclinical
CHEMBL5583869 7.22 EC50 60.0 Preclinical
CHEMBL4174142 7.1 IC50 80.0 Preclinical
CHEMBL4166227 7.1 IC50 80.0 Preclinical
CHEMBL4761334 7.05 EC50 90.0 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
2
5.5
1
6.0
6
6.5
7
7.0
1
7.5
3
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

CHLOROQUINE
CHEMBL76
Approved 1949
Properties Compare Identifier
Assay Landscape

Assay Landscape

12
Total Assays
24
Tested Compounds
1
Assay Types
Functional — 12 assays, 24 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 12 24 6.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine