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Target Snapshot

CHEMBL613103 Target Snapshot

833K · CELL-LINE · Homo sapiens

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20Compounds
4Assays
1Approved Drugs
20.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats 833K as ChEMBL target CHEMBL613103. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
833K
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL613103
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether 833K still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred Name833K
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein Label833K
UniProt AccessionN/A

833K

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as 833K.

Review name833K
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5020.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL321859 9.85 IC50 0.14 Preclinical
CHEMBL420481 9.04 IC50 0.92 Preclinical
CHEMBL321208 8.92 IC50 1.2 Preclinical
CHEMBL109032 8.68 IC50 2.1 Preclinical
CHEMBL107934 8.54 IC50 2.9 Preclinical
CHEMBL322789 8.25 IC50 5.6 Preclinical
CHEMBL107547 8.24 IC50 5.7 Preclinical
CHEMBL108601 8.15 IC50 7.0 Preclinical
CHEMBL322959 8.13 IC50 7.4 Preclinical
CHEMBL65 8.0 IC50 10.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
2
6.0
2
6.5
1
7.0
1
7.5
5
8.0
3
8.5
1
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

MITOMYCIN
CHEMBL105
Approved 1981
Properties Compare Identifier
Assay Landscape

Assay Landscape

4
Total Assays
17
Tested Compounds
1
Assay Types
Functional — 4 assays, 17 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 4 17 7.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine