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Target Snapshot

CHEMBL613127 Target Snapshot

Human orthopneumovirus · ORGANISM · Human orthopneumovirus

Back to Search Search this target Browse approvals Evidence Card
359Compounds
73Assays
4Approved Drugs
353.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Human orthopneumovirus as ChEMBL target CHEMBL613127. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Human orthopneumovirus
ORGANISM · Human orthopneumovirus
As of 2026-09-14
ChEMBL target ID
CHEMBL613127
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Human orthopneumovirus still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameHuman orthopneumovirus
Target TypeORGANISM
OrganismHuman orthopneumovirus
ChEMBL ↗ NCBI Taxonomy ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHuman orthopneumovirus
UniProt AccessionN/A

Human orthopneumovirus

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Human orthopneumovirus.

Review nameHuman orthopneumovirus
OrganismHuman orthopneumovirus
Clinical Profile

Clinical Phase Distribution

4
Approved
2
Phase III
5
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC5041.0
EC50312.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4446425 10.28 EC50 0.052 Preclinical
CHEMBL4297497 10.0 EC50 0.1 Clinical
CHEMBL4437054 9.7 EC50 0.2 Clinical
CHEMBL3410450 9.37 EC50 0.43 Clinical
CHEMBL4291143 9.3 EC50 0.5 Clinical
CHEMBL4855358 9.3 EC50 0.5 Preclinical
CHEMBL4878302 9.1 EC50 0.8 Preclinical
CHEMBL4297497 8.85 IC50 1.4 Clinical
CHEMBL4873528 8.8 EC50 1.6 Preclinical
CHEMBL4468815 8.7 EC50 2.0 Clinical
Distribution

pChEMBL Value Distribution

33
5.0
26
5.5
18
6.0
14
6.5
13
7.0
12
7.5
9
8.0
11
8.5
5
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

REMDESIVIR
CHEMBL4065616
Approved 2020
Properties Compare Identifier
MYCOPHENOLIC ACID
CHEMBL866
Approved 2004
Properties Compare Identifier
Assay Landscape

Assay Landscape

73
Total Assays
154
Tested Compounds
1
Assay Types
Functional — 73 assays, 154 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 71 147 6.2
cell-based format 2 7 5.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine