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Target Snapshot

CHEMBL613478 Target Snapshot

Xenopus laevis · ORGANISM · Xenopus laevis

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195Compounds
65Assays
4Approved Drugs
146.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Xenopus laevis as ChEMBL target CHEMBL613478. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Xenopus laevis
ORGANISM · Xenopus laevis
As of 2026-09-13
ChEMBL target ID
CHEMBL613478
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Xenopus laevis still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameXenopus laevis
Target TypeORGANISM
OrganismXenopus laevis
ChEMBL ↗ NCBI Taxonomy ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelXenopus laevis
UniProt AccessionN/A

Xenopus laevis

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Xenopus laevis.

Review nameXenopus laevis
OrganismXenopus laevis
Clinical Profile

Clinical Phase Distribution

4
Approved
2
Phase II
Assay Mix

Activity Type Distribution

EC50146.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2314253 11.0 EC50 0.01 Preclinical
CHEMBL2314255 10.46 EC50 0.035 Preclinical
CHEMBL10878 9.46 EC50 0.35 Approved
CHEMBL290895 8.6 EC50 2.5 Preclinical
CHEMBL15013 7.3 EC50 50.0 Preclinical
CHEMBL210952 7.22 EC50 60.0 Clinical
CHEMBL15318 7.16 EC50 70.0 Preclinical
CHEMBL2021957 7.16 EC50 70.0 Preclinical
CHEMBL3138445 7.16 EC50 70.0 Preclinical
CHEMBL2314257 7.03 EC50 93.5 Preclinical
Distribution

pChEMBL Value Distribution

31
5.0
41
5.5
15
6.0
5
6.5
7
7.0
0
7.5
0
8.0
1
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

BREXANOLONE
CHEMBL207538
Approved 2019
Properties Compare Identifier
AGOMELATINE
CHEMBL10878
Approved 2009
Properties Compare Identifier
PROPOFOL
CHEMBL526
Approved 1989
Properties Compare Identifier
Assay Landscape

Assay Landscape

65
Total Assays
91
Tested Compounds
2
Assay Types
Functional — 59 assays, 91 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 59 91 5.8
ADME — 6 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 6 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine