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Evidence Snapshot

A2058

CHEMBL613503 CELL-LINE Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T20:05:07Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL613503
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats A2058 as ChEMBL target CHEMBL613503. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
A2058
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL613503
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why A2058 matters

As of 2026-09-13

A2058 is reviewed as A2058; the current evidence base includes 30 approved drugs, 476 compounds, and 305 assays, with lead potency reaching pChEMBL 9.3.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 30 approved drugs, 476 compounds, and 305 assays for this target. The dominant activity type is IC50. CHEMBL3545252 is the current potency anchor at pChEMBL 9.3.

Use CHEMBL3545252 as the tractability anchor when discussing potency (pChEMBL 9.3).

Activity source · ChEMBL 36 via Core Engine
30 approved pChEMBL 9.3
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why A2058 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

476
Total Compounds
305
Total Assays
30
Approved Drugs
IC50: 314.0, EC50: 18.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL3545252
 9.3 IC50 Approved
No preferred name
CHEMBL94657
 9.2 IC50 Clinical
No preferred name
CHEMBL5612253
 9.0 IC50 —
No preferred name
CHEMBL159
 8.9 IC50 Approved
No preferred name
CHEMBL383824
 8.7 IC50 Clinical

Approved Drugs

Structure Compound First Approval
MIDOSTAURIN
CHEMBL608533
 2017
TEMSIROLIMUS
CHEMBL1201182
 2007
GEMCITABINE
CHEMBL888
 1996
DOCETAXEL
CHEMBL3545252
 1995
VINORELBINE
CHEMBL553025
 1994
PACLITAXEL
CHEMBL428647
 1992
ETOPOSIDE
CHEMBL44657
 1983
MITOMYCIN
CHEMBL105
 1981
DAUNORUBICIN
CHEMBL178
 1979
DOXORUBICIN
CHEMBL53463
 1974
CYTARABINE
CHEMBL803
 1969
VINBLASTINE
CHEMBL159
 1965
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T20:05:07Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL613503