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Target Snapshot

CHEMBL613507 Target Snapshot

CV-1 · CELL-LINE · Chlorocebus aethiops

223Compounds
59Assays
2Approved Drugs
94.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats CV-1 as ChEMBL target CHEMBL613507. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
CV-1
CELL-LINE · Chlorocebus aethiops
As of 2026-09-13
ChEMBL target ID
CHEMBL613507
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether CV-1 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCV-1
UniProt AccessionN/A

CV-1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as CV-1.

Review nameCV-1
OrganismChlorocebus aethiops
Clinical Profile

Clinical Phase Distribution

2
Approved
Assay Mix

Activity Type Distribution

IC5094.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL428125 8.49 IC50 3.2 Preclinical
CHEMBL63970 8.22 IC50 6.0 Preclinical
CHEMBL61 7.54 IC50 29.0 Approved
CHEMBL432749 7.24 IC50 58.0 Preclinical
CHEMBL106428 7.0 IC50 100.0 Preclinical
CHEMBL3350189 6.7 IC50 200.0 Preclinical
CHEMBL79247 6.68 IC50 210.0 Preclinical
CHEMBL313476 6.66 IC50 220.0 Preclinical
CHEMBL344644 6.66 IC50 220.0 Preclinical
CHEMBL309880 6.64 IC50 230.0 Preclinical
Distribution

pChEMBL Value Distribution

8
5.0
18
5.5
11
6.0
14
6.5
2
7.0
1
7.5
2
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PODOFILOX
CHEMBL61
Approved 1990
Assay Landscape

Assay Landscape

59
Total Assays
62
Tested Compounds
3
Assay Types
Functional — 43 assays, 62 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 40 62 5.9
organism-based format 3 0
ADME — 15 assays, 9 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 15 9 5.2
Toxicity — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine