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Target Snapshot

CHEMBL613517 Target Snapshot

NCI-H417 · CELL-LINE · Homo sapiens

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29Compounds
16Assays
1Approved Drugs
22.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NCI-H417 as ChEMBL target CHEMBL613517. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NCI-H417
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL613517
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether NCI-H417 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNCI-H417
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNCI-H417
UniProt AccessionN/A

NCI-H417

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as NCI-H417.

Review nameNCI-H417
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase III
Assay Mix

Activity Type Distribution

IC5022.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1771376 8.52 IC50 3.0 Preclinical
CHEMBL144698 7.4 IC50 40.0 Preclinical
CHEMBL318896 7.37 IC50 43.0 Preclinical
CHEMBL2013119 7.1 IC50 80.0 Clinical
CHEMBL142232 7.05 IC50 90.0 Preclinical
CHEMBL144606 7.0 IC50 100.0 Preclinical
CHEMBL317514 6.96 IC50 110.0 Preclinical
CHEMBL53463 6.64 IC50 230.0 Approved
CHEMBL609505 6.55 IC50 280.0 Preclinical
CHEMBL19569 6.48 IC50 330.0 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
4
5.5
3
6.0
3
6.5
5
7.0
0
7.5
0
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
Assay Landscape

Assay Landscape

16
Total Assays
20
Tested Compounds
1
Assay Types
Functional — 16 assays, 20 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 9 20 6.3
organism-based format 7 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine