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Target Snapshot

CHEMBL613522 Target Snapshot

PLC · CELL-LINE · Homo sapiens

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33Compounds
14Assays
3Approved Drugs
33.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats PLC as ChEMBL target CHEMBL613522. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
PLC
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL613522
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether PLC still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NamePLC
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPLC
UniProt AccessionN/A

PLC

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as PLC.

Review namePLC
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

3
Approved
2
Phase III
Assay Mix

Activity Type Distribution

IC5033.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2017441 8.1 IC50 8.0 Preclinical
CHEMBL1231160 6.52 IC50 300.0 Clinical
CHEMBL4798571 6.24 IC50 582.0 Preclinical
CHEMBL98 5.81 IC50 1534.0 Approved
CHEMBL5401822 5.47 IC50 3400.0 Preclinical
CHEMBL3355813 5.43 IC50 3700.0 Preclinical
CHEMBL5414116 5.4 IC50 4000.0 Preclinical
CHEMBL4544872 5.36 IC50 4340.0 Preclinical
CHEMBL5396168 5.22 IC50 6000.0 Preclinical
CHEMBL3355820 5.19 IC50 6400.0 Preclinical
Distribution

pChEMBL Value Distribution

12
5.0
1
5.5
1
6.0
1
6.5
0
7.0
0
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

14
Total Assays
27
Tested Compounds
1
Assay Types
Functional — 14 assays, 27 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 14 27 5.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine